Acetyl hexapeptide 1
Product Properties
1. Product name: Acetyl Hexapeptide-1
2. Other name: melitane,melitane Peptide,Melitane Peptide 98%,hexapeptide 1
3. Appearance: white powder
4. Content: ≥99% (HPLC)
5. Chemical formula: C43H59N13O7
6. CAS No.: 448944-47-6
7. Molecular weight: 870.01
8. Usage：Cosmetic Raw Materials
Payment Method: T/T, Western Union, Pay Pal, Alibaba Assurance Account
14 years experience on natural ingredients industry.
product description
Acetyl Hexapeptide-1, also known as Melitane®, is a high-purity hexapeptide active ingredient. Its molecular structure mimics natural signalling peptides within the human body, exhibiting outstanding biomimetic activity. Composed of six specific amino acids, this peptide efficiently participates in skin cell signalling pathways, regulating melanin production and distribution to help improve skin tone evenness and promote a healthy, radiant complexion.
Within the functional skincare sector, it is extensively incorporated into premium serums, daily emulsions, photoprotective formulations, and other functional products, progressively establishing itself as a pivotal active ingredient within peptide-based skincare systems. Its unique mechanism of action confers irreplaceable scientific value and market competitiveness within cosmetic formulations.
Le-Nutra Ingredients, as a specialist peptide ingredient supplier, maintains a longstanding commitment to the research, development, and production of high-end functional peptides. We possess extensive expertise in peptide chain synthesis processes, purification techniques, and quality control, ensuring high purity, stability, and batch consistency for core products such as Acetyl Hexapeptide-1. Through continuous optimisation of synthesis workflows and production conditions, we guarantee every batch meets international cosmetic active ingredient standards, providing clients with reliable, traceable raw material supply.
Product Characteristics
1. Stable Molecular Structure
Following acetylation modification, melitane exhibits enhanced molecular stability, effectively resisting hydrolysis and degradation from external environments. This ensures sustained activity throughout skincare formulations and during application to the skin.2. Outstanding Bio-mimetic Activity
This peptide mimics the action mechanism of α-MSH (α-melanocyte-stimulating hormone), binding to the skin's MC1-R receptor to participate in pigment regulation and related cellular responses. This enables scientifically controllable activity within functional skincare formulations.3. Excellent formulation compatibility
Melitane Peptide is 98% water-soluble, facilitating seamless incorporation into aqueous systems, emulsions, serums, and diverse skincare matrices. Approved by multiple national cosmetic ingredient registries, it suits development across various functional skincare product types.4. High Safety Profile and Low Irritation
This peptide is a non-oily, non-comedogenic ingredient with low sensitisation risk. At typical skincare formulation concentrations, it demonstrates excellent skin tolerance and can be safely incorporated into diverse premium skincare products.
Product Efficacy
1. Promotes Natural Pigment Regulation
Hexapeptide 1 stands as a star active ingredient in contemporary hair care and pigment regulation. It acts upon melanocytes within the hair follicle, stimulating the production of melanin granules and facilitating their migration towards the hair shaft. This addresses the root cause of greying hair. Clinical and experimental data demonstrate that prolonged use of serums or hair care formulations containing this peptide effectively reduces the proportion of grey hair, restoring a more natural, deeper shade. Additionally, within functional skincare formulations, it participates in skin pigment regulation, contributing to an even, healthy complexion.
2. Sunless Tanning and Skin Tone Optimisation
This ingredient induces natural bronze tones without relying on UV exposure, making it suitable for developing formulations targeting safe tanning or skin tone evenness. For areas with uneven pigmentation, dullness, or hyperpigmentation, it synergistically regulates pigment distribution, resulting in a more balanced, naturally luminous complexion. This characteristic lends significant innovative application value in daily skincare serums, brightening products, and functional protective formulations.
3. Repair and Anti-Ageing
UV exposure triggers pro-inflammatory cytokine release, causing photodamage to the skin. Acetyl Hexapeptide-1 inhibits inflammatory mediators such as IL-1α while activating skin DNA repair pathways, thereby reducing sunburn cell formation and safeguarding epidermal and dermal structural integrity. Its anti-inflammatory and restorative functions not only alleviate fine lines and wrinkles caused by photoaging but also enhance skin resilience against environmental stressors, maintaining a healthier, firmer complexion.
4. Enhancing Skin's Natural Sun Protection
By increasing melanin content within the skin, it constructs a natural photoprotective barrier, elevating tolerance to damage from sunlight and environmental light exposure. This mechanism not only reduces UV-induced oxidative stress and hyperpigmentation but also provides functional precursor support for daily sunscreens and photoprotective products, making it an ideal active ingredient in premium sun protection and multifunctional skincare formulations.
Market Applications
1. Scalp and Hair Care Products
Acetyl Hexapeptide-1 serves as an ingredient for scalp care and hair treatments, suitable for products such as anti-greying serums, darkening shampoos, and scalp repair sprays. Its water solubility and formulation compatibility allow seamless integration with other scalp and hair care components, facilitating the development of premium scalp care ranges across diverse product formats.2. Premium Sun Protection and After-Sun Care Products
Suitable for high-end sun protection and post-sun skincare formulations, including pre-sun intensifying serums, after-sun repair emulsions, and bio-sunscreens. Its excellent emulsion system adaptability and stability facilitate incorporation into daily skincare and photoprotection formulations.
3. Cosmetics and Skin Tone Correction Products
Suitable for self-tanning body lotions, skin-evening creams, and other colour-correcting formulations. Serves as a multifunctional skincare or makeup primer, dispersing uniformly in aqueous, emulsion, or serum systems to facilitate development of premium skincare and cosmetic products.4. Men's Grooming Products
Suitable for men's hair and beard care products, such as anti-greying serums, grooming kits, or scalp care sprays. Hexapeptide 1 demonstrates excellent compatibility in lotion, serum, or spray formulations, supporting the development of premium men's grooming products.
Market Trends
‘Biological Photo-protection’: Consumers are shifting from basic SPF coverage towards cellular-level defence, with AH-1 perfectly aligning with this premium demand.
‘Hair-Skin Integration’: By 2026, scalp care will be viewed as an extension of skincare, driving explosive growth for peptide ingredients that address greying hair at a biological level.
Replacing Traditional Hair Dye: With heightened awareness of chemical dye allergies, solutions like acetyl hexapeptide-1 that reverse greying at its root are becoming the preferred choice in ‘Clean Beauty’.
Precision Aesthetics: Post-laser treatments, utilising AH-1 for pigmentation management and DNA repair has emerged as a new trend in clinic-grade skincare.
FAQ
Q1: What is the difference between Acetyl Hexapeptide-1 and Acetyl Hexapeptide-8?
A: These are two entirely distinct peptides. Hexapeptide-8 (Argireline®) primarily inhibits muscle contraction to diminish expression lines; whereas Hexapeptide-1 mimics melanocyte-stimulating hormone for hair darkening, tanning, and photoprotection.
Q2: Is this ingredient stable in formulations?
A: It is highly stable. Being readily soluble in water, it is recommended for incorporation during the final stages of formulation. It performs excellently within a pH range of 4.0-7.0.
Q3: Is it vegan?
A: Yes. Our Acetyl Hexapeptide-1 is entirely chemically synthesised in the laboratory and contains no animal-derived components.
Q4: How does it differ from standard peptide ingredients?
A: This ingredient features acetylation modification and a specifically designed amino acid sequence, exhibiting distinct biomimetic activity. It acts more precisely within cellular signalling regulation and pigment-related pathways, making it suitable for high-end functional skincare development.
Q5: Do you offer sample testing and small-batch procurement?
A: Yes. We can provide sample specifications and flexible procurement solutions tailored to clients' R&D or evaluation needs, facilitating formulation validation and product development.
Q6: Does this raw material comply with cosmetic regulations?
A: Acetyl Hexapeptide-1, as a peptide ingredient for cosmetics, is suitable for compliant skincare product development. Specific regulatory compliance documentation can be provided for target markets (e.g., EU, USA, Asia).
Why Choose Le-Nutra's Acetyl Hexapeptide 1
As a leading manufacturer with years of expertise in plant extraction and peptide synthesis, Le-Nutra not only supplies high-purity acetyl hexapeptide 1 raw materials but is also committed to creating profound commercial value through our end-to-end service. Leveraging our factory-direct model of ‘Research Centre Direct to Warehouse’, we eliminate intermediary mark-ups entirely, ensuring you access premium-quality raw materials at highly competitive source pricing.
Our specialised application laboratories serve not only as production hubs but as your technical support arm. We assist in optimising formulation architecture, provide comprehensive stability testing data and ingredient compatibility advice, ensuring optimal efficacy of the raw material within your finished products. Regarding quality control, we implement stringent controlled processes. Each batch undergoes precise HPLC/MS testing, accompanied by comprehensive COA, MSDS, and testing spectra documentation. We firmly support third-party authoritative testing, ensuring quality and safety traceability. Furthermore, leveraging substantial stock reserves and a flexible production system, we offer bespoke packaging solutions ranging from 1g R&D samples to 10kg industrial bulk orders. We guarantee lightning-fast dispatch within 24 hours, enabling your brand to seize competitive advantage in fiercely contested markets through unparalleled responsiveness.
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