Herbal Extract
China Wholesale Green Coffee Bean Extract Chlorogenic Acid Powder for Supplements
Product Properties
1.Botanical Source: Coffea Arabica L; Lonicera japonica Thunb.
2.Appearance: 10%, 30%, 50%: Yellow-brown to brown powder, 98%: Off-white to white powder
3.Specification: 10%, 30%, 50%, 98%, also Honeysuckle Extract available
4.CAS: 327-97-9
5.Functions: Aids in weight loss, help to lower blood pressure, blood sugar, etc.
6.Applications: Dietary Supplements, Healthy Food Product, Medicines.
7.Package: Vacuum Aluminum Foil Bag; Fiber Drum for 25kg with inside double layer food grade poly bag
product description
Chlorogenic Acid Powder can be extract from Green Coffee Bean(Coffea Arabica L) and Honeysuckle(Lonicera japonica Thunb.). Le-Nutra Ingredients offers both plant origins. Chlorogenic Acid Powder can promote weight loss in overweight and obese people, and also has the effects of lowering blood pressure, blood lipids, blood sugar, anti-inflammatory and antiviral, anti-tumor, anti-oxidation, anti-fatigue, strengthening the muscles and bones, and anti-aging.
Product Introduction
- Green Coffee Bean Extract Chlorogenic Acid Powder is a lipid compound synthesized from caffeic acid and quinic acid with an unsaturated double bond. Currently, it's main commercial source is the extracts of plant-like materials, such as plants of the Eucommiaceae family, Lonicera japonica and Asteraceae, with high content in Eucommia leaves, Dandelion, Honeysuckle, Green Coffee Bean. It's has antibacterial and antiviral properties, anti-tumor, antioxidant, hypoglycemic and lipid-lowering, and UV-resistant and radiation resistant physiological functions, and it's widely used in food, pharmaceuticals, and health care products. It is widely used in food, medicine and health care products.
Technical Data Sheet
| Product Name | Green Coffee Bean Extract Chlorogenic Acid; Honeysuckle Extract Chlorogenic Acid |
| Latin Name | Coffea Arabica L; Lonicera japonica Thunb. |
| Carrier | None |
| Solvent Used | Ethanol Water |
| Country of Origin | China |
| Sterilization | NO-IR&GMO free |
| ITEM | SPECIFICATION |
| Physical Data | |
| Appearance | Yellow Brown Powder |
| Odor & taste | Characteristic |
| Sieve analysis | 95% pass 80 mesh |
| Chlorogenic acids | ≥10%; ≥30%; ≥50%; ≥98% |
| Caffeine | ≤5% |
| Loss on Drying | ≤5.0% |
| Sulphated Ash | ≤5.0% |
| Ethanol Residues | ≤5000ppm |
| N-hexane residual | ≤290ppm |
| Methylene Chloride residual | ≤600ppm |
| Heavy Metals | ≤10ppm |
| Lead(Pb) | ≤1ppm |
| Arsenic(As) | ≤1ppm |
| Cadmium(Cd) | ≤1ppm |
| Mercury(Hg) | ≤0.1ppm |
| Microbiology | |
| Total Plate Count | ≤1000cfu/g |
| Yeast & Mold | ≤100cfu/g |
| E.Coli | ≤3MPN/g |
| Salmonella | Negative |
| Staphylococcus | Negative |
| Conclusion | The product meets the testing requirements by inspection |
| Notes | Preserve in well-closed containers, protected from light and moisture, and store at controlled room temperature. |
Product Functions
- 1. Antioxidant effectsGreen Coffee Bean Extract Chlorogenic Acid Powder is a potent natural antioxidant that protects cells from oxidative damage by scavenging free radicals, inhibiting lipid peroxidation and reducing oxidative stress. The phenolic hydroxyl group in its molecular structure can directly neutralize reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as superoxide anion, hydroxyl radical and nitric oxide. It has been found that the antioxidant capacity of chlorogenic acid is comparable to that of vitamin C and vitamin E, and even performs better under certain conditions. For example, in in vitro experiments, chlorogenic acid significantly reduced the oxidation of low-density lipoprotein (LDL), thereby reducing the risk of atherosclerosis. In addition, it enhances cellular defense against oxidative damage by activating the nuclear factor E2-related factor 2 (Nrf2) pathway and promoting the expression of antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase). This effect has important potential in slowing down aging, preventing cancer and neurodegenerative diseases (e.g. Alzheimer's disease).
2. Anti-inflammatory effects
Green Coffee Bean Extract Chlorogenic Acid Powder exerts anti-inflammatory effects by modulating multiple inflammatory signaling pathways. It inhibits the activation of nuclear factor κB (NF-κB), which reduces the release of pro-inflammatory cytokines (e.g. TNF-α, IL-6 and IL-1β). Animal studies have shown that chlorogenic acid reduces joint swelling and inflammatory cell infiltration in a rheumatoid arthritis model. In addition, it inhibits the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), reduces the production of prostaglandin E2 (PGE2) and nitric oxide (NO), and alleviates the inflammatory response. Preclinical studies have shown that chlorogenic acid has a significant ameliorative effect on intestinal inflammation (e.g. ulcerative colitis) and skin inflammation (e.g. contact dermatitis). Its anti-inflammatory mechanism involves not only immune cell regulation, but may also work indirectly by repairing the intestinal barrier function and regulating intestinal flora.
3. Metabolic regulation
Green Coffee Bean Extract Chlorogenic Acid Powder has a bi-directional regulation of glucose and lipid metabolism. It can inhibit the activity of intestinal α-glucosidase and delay the digestion and absorption of carbohydrates, thus reducing the postprandial blood glucose peak. Meanwhile, chlorogenic acid can enhance the glucose uptake capacity of skeletal muscle and liver and improve insulin resistance by activating the AMP-dependent protein kinase (AMPK) pathway. Animal studies have shown that long-term supplementation of chlorogenic acid reduces body weight, visceral fat content and serum triglyceride levels in obesity model mice. In terms of lipid metabolism, chlorogenic acid inhibits hepatic fatty acid synthase (FAS) activity, reduces lipogenesis, and promotes fatty acid β-oxidation. Clinical trials found that daily intake of 300-400 mg chlorogenic acid significantly improved fasting blood glucose and lipid indices in patients with metabolic syndrome, suggesting its application value in diabetes and obesity management.
4. Neuroprotective effects
Green Coffee Bean Extract Chlorogenic Acid Powder can protect the nervous system through multiple pathways. First, its antioxidant properties reduce oxidative damage to mitochondria in nerve cells and maintain energy metabolic homeostasis. Secondly, it can inhibit β-amyloid (Aβ) aggregation and tau protein hyperphosphorylation, both of which are key pathological features of Alzheimer's disease. Animal experiments have shown that chlorogenic acid improves learning memory ability in mice modeled with cognitive impairment. In addition, chlorogenic acid can regulate neurotransmitter levels, such as increasing acetylcholine content in the hippocampus, while inhibiting monoamine oxidase (MAO) activity and delaying the degeneration of dopaminergic neurons. In a model of cerebral ischemia-reperfusion injury, chlorogenic acid significantly reduced the size of cerebral infarcts by inhibiting microglia hyperactivation and reducing the release of pro-inflammatory factors. These findings provide a theoretical basis for its application in neurological diseases such as Parkinson's disease and stroke.
- 5. Antibacterial and antiviral effectsHoneysuckle Extract Chlorogenic Acid Powder has an inhibitory effect on a variety of pathogenic microorganisms. Its antibacterial mechanism includes disrupting the integrity of bacterial cell membranes, inhibiting biofilm formation and interfering with the activity of key enzymes in energy metabolism. Studies have shown that chlorogenic acid exhibits broad-spectrum antibacterial activity against Gram-positive and negative bacteria such as Staphylococcus aureus and Escherichia coli, with a minimum inhibitory concentration (MIC) as low as 32 μg/mL. In the antiviral area, chlorogenic acid can exert its effects by blocking the entry of viruses into host cells. For example, it competitively binds to the influenza virus hemagglutinin protein, preventing the virus from binding to the host cell salivary acid receptor. Recent studies have also found that chlorogenic acid inhibits the major protease (3CLpro) of SARS-CoV-2, and computer simulations have shown that its free energy of binding reaches -7.8 kcal/mol, suggesting potential antiviral applications against the new coronavirus.
Product Applications
1. Functional foods and health products
As a natural functional ingredient, Green Coffee Bean Extract Chlorogenic Acid Powder is widely used in weight management and blood sugar control health products. For example, the capsules of “Coffee Bean Extract” launched by an international brand contain 45% Chlorogenic Acid per capsule, which is claimed to help reduce weight by inhibiting fat absorption. In the food industry, chlorogenic acid is used as a natural preservative, and its antimicrobial properties can extend the shelf life of foods such as bread and fruit juices. In Japan, chlorogenic acid has been approved to be added to sports drinks to utilize its antioxidant properties to alleviate oxidative stress after exercise. In addition, chlorogenic acid-rich roasted coffee (12% chlorogenic acid in light roasted coffee) has been developed as a “healthy coffee” product with cardiovascular protection. The European Union's EFSA has approved a health claim for chlorogenic acid: “helps to maintain normal blood sugar levels”.
2. Pharmaceutical field
In drug discovery, Honeysuckle Extract Chlorogenic Acid Powder is used as a lead compound in the development of antidiabetic drugs. A chlorogenic acid derivative (Patent No. WO2020156576A1) developed by a pharmaceutical company showed stronger PPARγ agonistic activity than the parent compound, and reduced HbA1c by 1.2% in phase II clinical trials. In the cardiovascular field, chlorogenic acid injection (included in the Chinese Pharmacopoeia) is used for the treatment of coronary heart disease, which can improve myocardial blood supply by inhibiting platelet aggregation. In dermatological applications, cream containing 5% chlorogenic acid has been shown to be effective in relieving itching symptoms in patients with atopic dermatitis (EASI score reduced by 40%). Recent studies have also found that chlorogenic acid nanoparticles can penetrate the blood-brain barrier, and a phase I clinical trial is underway for the treatment of Alzheimer's disease (NCT04863248).
- 3. Cosmetic industryHoneysuckle Extract Chlorogenic Acid is widely used in anti-aging skin care products. A high-end brand launched a “polyphenol repair essence” containing 3% chlorogenic acid complex, clinical trials show that the depth of wrinkles reduced by 18% after 8 weeks of use. Its mechanism includes inhibiting matrix metalloproteinase (MMP-1) activity and promoting collagen synthesis. In sunscreen products, chlorogenic acid complexed with titanium dioxide can boost SPF by 2-3 times while reducing UV-induced DNA damage. Soothing masks for sensitive skin can reduce the Erythema Index (EI) by 35% in 30 minutes through the anti-inflammatory properties of chlorogenic acid. In addition, chlorogenic acid's tyrosinase inhibitory activity (IC50=28μM) makes it a natural whitening ingredient, and a brand of blemish-removing serum has been certified by China's CFDA.
4. Agriculture and plant protection
In sustainable agriculture, Green Coffee Bean Extract Chlorogenic Acid has been developed as a biopesticide. 0.5% chlorogenic acid in water is 72% effective against gray mold of tomato without chemical pesticide residues. As a plant growth regulator, 10μM chlorogenic acid treatment can increase the length of rice seedling roots by 40%, and the mechanism is related to the activation of growth hormone signaling pathway. In the field of post-harvest preservation, 1% chlorogenic acid coating treatment can reduce strawberry decay rate by 65% and extend the freshness period by 5-7 days. The latest application is to compound chlorogenic acid with chitosan to make biodegradable mulch film, which can not only inhibit soil-borne diseases (such as Fusarium), but also naturally decompose in the soil to reduce white pollution.
5. Food processing and preservation
Green Coffee Bean Extract Chlorogenic Acid Powder is used as a natural color protectant in meat processing. 0.02% addition of chlorogenic acid can reduce the nitrite residue of sausage by 50% while maintaining good color stability. In dairy products, chlorogenic acid-whey protein complexes are used in the development of functional yogurt, which can increase the DPPH free radical scavenging rate of the product by 3 times. In the bakery industry, the Maillard reaction inhibition properties of chlorogenic acid have been utilized to reduce acrylamide production by as much as 45% with the addition of 0.1%. In the beverage industry, chlorogenic acid is compounded with vitamin C as an antioxidant system to increase the retention of catechins in green tea beverages by 30% over the shelf life. A recent Japanese patent (JP2021178467A) also developed chlorogenic acid nanoemulsification technology for enhancing bioavailability in fat-soluble foods.
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